Macedonius ascended onto the throne of the king of cities with the support of the emperor Constantius and the arian-minded bishops, who removed from the throne the orthodox and canonical archbishop Paul and expelled him in Thessalonika.
The acute conflict between Orthodox and Arian-minded and the intercession of the orthodox emperor of the West Constas, allowed the return of Paul in Constantinople in 346 and the dismissal of Macedonius.
After the deposition of Paul in 350, the emperor Constantius reinstated Macedonius on the throne, who supported the arian faith of the emperor and the persecutions against Orthodox bishops.
Macedonius, of course, did not introduce the heresy of the Pneumatomachi, for these were a product of Arianism; but because these heretical teachings came into existance during his hierarchy, and he did not prevent their spreading, his name is often linked with these.
The all-powerful Acacius, Bishop of Caesaria in Palaistine, managed with the assistance of Constantius to summon a synod in Constantinople in 360, which deposed the Orthodox bishops. This synod also condemned and deposed Macedonius, who resorted to the suburbs of Constantinople until his death in 364.